WebOct 17, 2024 · What Is PSSM in Horses? Polysaccharide Storage Myopathy (PSSM) is a disease that results in the abnormal accumulation of glycogen (a form of sugar that is stored in muscles) which causes painful muscle cramping or tying up. There are two types of PSSM: Type 1 PSSM: caused by a genetic mutation in the GYS1 gene and can be … Tying up refers to painful muscle cramping in horses. University of Minnesota veterinarians identified PSSM as a form of tying up. This disorder causes the horse’s body to abnormally store or store too much sugar (glycogen) in the muscles. See more Insulin is a hormone that controls a horse’s blood sugar level. Thus, sugar from a horse’s diet can stimulate an insulin response. PSSM horses tend to be more sensitive to insulin. Insulin can further worsen PSSM … See more Type 1 PSSM is caused by a mutation in the GYS1 gene and occurs in over 20 horse breeds. It’s likely an old genetic mutation that … See more Type 2 PSSM refers to PSSM that occurs without genetic mutation. This PSSM is more common in warmbloods. See more
What is PSSM in horses? - Vet Help Direct
WebThe PSSM1 variant is believed to be an old mutation that may have been under positive selection in some draft breeds, particularly the Belgian horse. This mutation may have been advantageous to horses that had daily work schedules with limited sugar feed intake. Testing for PSSM1 can help to inform clinical, management, and breeding decisions. WebJan 12, 2024 · The usual starting dose for EPSM horses of average size is 2 mg/day of selenium and 5000 IU of vitamin E oil. Higher intakes of vitamin E, up to 10,000 iu can be of benefit to some horses. Another important antioxidant is glutathione. L-glutamine supplementation can support these levels and also doubles as an alternate energy source … mosby fox 45
Polysaccharide Storage Myopathy in Horses
WebPSSM was first thought to be a problem specific to Quarter Horses, but was soon found to affect other muscular breeds like Appaloosas, Paints, draught horse breeds, Haflingers and heavy warmbloods. Such breeds are affected mainly with Type 1 PSSM, a variant caused by a genetic mutation. The second variant, Type 2 PSSM can affect all horses ... WebPolysaccharide storage myopathy (PSSM1) is characterized by the abnormal accumulation of the normal form of sugar stored in muscle (glycogen) as well as an abnormal form of sugar (amylase-resistant polysaccharide) in muscle tissue. By definition horses with PSSM1 have a distinctive genetic mutation in the gene. WebEspecially Thoroughbreds are suffering from MH, and the symptoms are thought to be induced by different stress factors (Valberg et al., 1999). PSSM is causing ER in e.g. Quarter Horses (QH) and is a neuro-muscular disorder. Horses with PSSM are suggested to have an enhanced glucose clearance from the bloodstream (De La Corte et al., 2002). mosby florida homes