Inbred strain mouse
WebInbred mouse strains have important differences in their behavioral and neuroanatomical characteristics, and in their susceptibility to neurotoxic insults (Schauwecker, 2002 ). Two commonly used inbred strains in transgenic studies … Web7 rows · The Mouse Genome Informatics (MGI) database is a reliable source of official nomenclature for ...
Inbred strain mouse
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WebInbred strains of mice are defined as strains that have been maintained by successive brother to sister matings over more than 20 generations (Green, 1975). Repetitive … WebInbred mouse strains are bred within a closed colony (by sibling matings) to maintain certain defining characteristics. Animals that result from at least 20 consecutive generations of brother x sister matings are considered inbred. C57BL/6J sister brother 20 or more generations C57BL C57BL/6 C57BL/10 C57BL/6J
WebA second inbred mouse strain frequently used in transgenic studies is the C57BL/6 strain. This strain is excellent for certain cognitive behavior tests ( Voikar et al. , 2001 ). However, since the C57BL/6 strain is inherently less exploratory and more anxious ( ibid ), this strain may be difficult for detecting hypokinesia. WebSome inbred strains have features that are advantageous to transgenic and embryonic stem (ES) cell technology: the large pronuclei of FVB mice are useful for gene transfer experiments...
WebApr 5, 2024 · Jackson Laboratory (JAX) and University of Connecticut Health Center Assistant Professor Christine Beck, Ph.D., led a team that explored the genomes of … WebChoosing an optimal mouse strain for preliminary assessment of neuronal complications is therefore imperative. In this study, we systematically compared the behavioral, cognitive, cholinergic, and inflammatory impairments of outbred ICR and inbred C57BL/6 mice strains subject to scopolamine-induced amnesia.
WebApr 13, 2024 · The Inbred Strain Variant Database (ISVdb) offers an interface to query sequence variants of inbred strains associated with the Collaborative Cross 2. The …
WebThe inbred strain A mouse appears to be the most susceptible to lung tumors, and forms the basis of a lung tumor bioassay, with tumors inducible within 8 weeks or less of treatment. Susceptibility of various strains to the initiation and/or promotion of skin tumors has also been shown to differ greatly ( Chouroulinkov et al. , 1988; Steinel and ... the hawks nestWebApr 15, 2015 · By 1909, the first inbred strain, DBA, was created and the era of modern mouse genetics had begun ( Russell, 1978 ). Since then, hundreds of inbred strains have been developed. Box 1 Glossary. … the hawksworth familyWebJul 7, 2024 · Inbred strains of mice and rats are invaluable animal resources for studying the genetic bases of phenotypic variation. They have been obtained through brother–sister mating for more than 20 generations, so all individuals have the same genome (isogenic) and each individual is homozygous at each locus. the hawkswell sligoWebAug 31, 2024 · By 20 generations of full-sib mating, individuals are expected to be 99.8% IBD, and the strain is considered to be operationally inbred (Green 1981; Lyon and Searle … the hawkswood groupWebMalaria is a complex infectious disease in which the host/parasite interaction is strongly influenced by host genetic factors. The consequences of plasmodial infections range … the hawkwell practiceWebInbred strains are defined as animals produced by a minimum of 20 generations of brother-sister mating, traceable to a single founding pair. Individuals of an inbred strain are genetically uniform, also known as isogeneic. the hawkswellWebAug 24, 2010 · Current inbred strains of mice are essential animal models for laboratory research with unquestionable contributions to many research fields. Nevertheless, they are not as simple as we would like from a genetic point of view. Although one of their main properties is the expected genetic homogeneity between individuals of the same strain, … the hawkstone