Cytosin permease
WebFeb 1, 1996 · The efflux of cytosine from cytosine permease-less cells has also been studied and shows first order kinetics. A diffusion coefficient of 5.7 per 10- minus 8 cm per S- minus 1 has been evaluated ... WebJul 17, 2006 · A genome-wide search for cytosine permease homologues identified two uncharacterized candidate genes, designated FCY21 and FCY22, both of which exhibit …
Cytosin permease
Did you know?
WebAbstract. Flucytosine (5-FC) is an antifungal agent commonly used for treatment of cryptococcosis and several other systemic mycoses. In fungi, cytosine permease and … WebOct 1, 2008 · Abstract. We found previously that inactivation of the FCY2 gene, encoding a purine-cytosine permease, or the HPT1 gene, encoding the hypoxanthine guanine phosphoribosyl transferase, enhances cisplatin resistance in yeast cells. Here, we report that in addition to fcy2Δ and hpt1Δ mutants in the salvage pathway of purine nucleotide …
WebThe purine‐cytosine permease (PCP) of the yeast Saccharomyces cerevisiae was detected by immunological methods. Using antibodies directed against synthetic peptides, whose … WebThe first step in the metabolism of cytosine is the deamination to uracil. Many fungi and bacteria including B. subtilis and several ... as an antitumor agent 16 but was later found to be an effective antimycotic. 17 5-FC is transported into fungal cells by cytosine permease and the active form is only formed upon conversion into 5 ...
WebJul 9, 2010 · Moreover, several genes coding cytosine transporters have been identified in S. cerevisiae [28–30]. Given the close phylogenetic relationship between S. cerevisiae and C. glabrata, one may speculate that several genes coding cytosine permease analogs are also present in the C. glabrata genome. WebThe purine‐cytosine permease (PCP) of the yeast Saccharomyces cerevisiae was detected by immunological methods. Using antibodies directed against synthetic peptides, whose sequences were derived from the primary structure of the PCP, immunoprecipitation of [35 S]methionine‐labelled PCP was achieved either from cellular extracts or from in vitro …
Web"The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product." Mol Microbiol 4(4);585-96. PMID: 2191181. Yao05: Yao L, Li Y, Wu Y, Liu A, Yan H (2005). "Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase."
WebFlucytosine is taken up by fungal cells via the enzyme cytosine permease. It is converted intracellularly first to 5-FU and then to 5- fluorodeoxyuridine monophosphate … son in law actorsWeb1 Mechanism of Action. Flucytosine is transported into susceptible fungal cells by the fungus-specific enzyme cytosine permease and converted in the cytoplasm by cytosine deaminase to 5-fluorouracil (5-FU), a potent antimetabolite. 5-FU is phosporylated and … small lobster tailsWebMar 18, 2024 · 5-FC exerts its antifungal effects by interfering with both deoxyribonucleic acid (DNA) and protein synthesis. 5-FC is transported into susceptible fungi by cytosine permease then deaminated to 5-fluorouracil (5-FU) by cytosine deaminase . The absence of cytosine deaminase in mammalian cells allows selective effects on fungal cells . small local businesses in arizonaWebcytosine, a nitrogenous base derived from pyrimidine that occurs in nucleic acids, the heredity-controlling components of all living cells, and in some coenzymes, substances that act in conjunction with enzymes in chemical … son in law danceWeb1 Mechanism of Action. Flucytosine is transported into susceptible fungal cells by the fungus-specific enzyme cytosine permease and converted in the cytoplasm by cytosine deaminase to 5-fluorouracil (5-FU), a potent antimetabolite. 5-FU is phosporylated and incorporated into RNA, where it causes miscoding. son-in-law definitionWebNational Center for Biotechnology Information small loan with low interestWebMay 1, 1997 · The purine-cytosine permease (PCP) is an active transporter located in the plasma membrane of the yeast Saccharomyces cerevisiae This protein mediates purine (adenine, guanine, and hypoxanthine ... son in law birthday card