WebMDA-MB-231 cancer cells were encapsulated in 0.5 to 10 mg⋅mL −1 type I collagen and categorized based on their motility over 6 h [high motility (HM): migrated >15 μm in 2 h ( … WebMar 31, 2024 · As shown in Figure 1B, it could be observed that fibril density is increased with collagen monomer concentration. The mean pore size was quantified using an image-based toolbox and measured to be 11.07 ± 0.62 µm and 3.74 ± 0.75 µm for 1 mg/mL and 3 mg/mL collagen concentrations, respectively ( Figure 1 C).
Effects of collagen density on cardiac fibroblast ... - ResearchGate
WebMay 19, 2003 · Experiments were carried out to determine the effects of alterations in collagen density and ECM stiffness on the behavior of isolated heart fibroblasts. In vitro bioassays were performed to measure the effects of changes in collagen concentration (0.75–1.25 mg/ml) on adhesion, migration, spreading, and gene expression by heart … WebThe collagen concentrations of the four cardiac chambers of normal hearts were determined chem-ically. Right ventricles and atria contained significantly higher collagen concentrations than did left ventricles and atria. The atria contained twice the collagen … pin the country on the map game
Extracellular Matrix in Cardiac Tissue Mechanics and Physiology: Role of Collagen
WebNov 9, 2024 · 1. Introduction. Collagen, an important protein produced by the body, is the main structural protein found in the skin, tendon, and bone. The word collagen originates from a Greek word that “kola” means gum and “gen” means producing. Collagen is considered to be one of the most useful biomaterials. WebSep 14, 2024 · A high-density collagen matrix, rather than a low-density matrix, decreases T cell abundance and cytotoxic T cells but upregulates regulatory T cells [123, 124]. Aligned fibers and collagen density around vascular regions and epithelial cancer cells restricted the migration of T cells and limited their entry into the tumor mass [ 125 ]. WebAug 4, 2006 · This similar pattern raised the question of whether cell density or collagen concentration more influenced these events. (2) To isolate these effects, the contraction kinetics of the HM construct were compared to those of a new construct (L5K) with equivalent cell-to-collagen ratio (0.4) but half the cell density (500K MSCs/mL) and half … pin the country