WebJul 7, 2008 · It is envisioned that the partitioning apparatus must consist of elements that are analogous to those involved in chromosome segregation in eukaryotic cells: a centromere binding protein, a mechanism to move the chromosomes towards the cell poles and, possibly, a mechanism of condensing the nascent chromosomes. The parABS system is a broadly conserved molecular mechanism for plasmid partitioning and chromosome segregation in bacteria. Originally identified as a genetic element required for faithful partitioning of low-copy-number plasmids, it consists of three components: the ParA ATPase, the ParB DNA-binding protein, and the cis-acting parS sequence. The parA and parB genes are typically found in the same operon, with parS elements located within or adjacent to this operon…
The bacterial ParA-ParB partitioning proteins - ScienceDirect
WebParb family transcriptional regulator, chromosome partitioning protein; Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity) (290 aa) Predicted Functional Partners: WebAbstract Objective: To identify inhibitors of the essential chromosome partitioning protein ParA that are active against Mycobacterium tuberculosis. Methods: Antisense expression of the parA orthologue MSMEG_6939 was induced on … scott d harris richmond va
The chromosome partitioning protein, ParB, is required for …
WebEach system depends on a site-specific DNA binding protein to recognize and assemble a partition complex at a centromere-like site, commonly called parS. Many plasmid, and … Web1995). Partitioning has been hypothesized to be a necessary prerequisite for cytokinesis, which, in E. coli cells, requires a period of post-replication protein synthesis (Donachie and Begg, 1989). It is not known whether this period of protein synthesis supplies proteins for chromosome partitioning or cell division. The WebMar 15, 2024 · SMC is a DNA-associated protein that can mediate DNA compaction and may play a role in the early phases of chromosome partitioning. SMC proteins (also known as condensins) have been a subject of significant interest in bacterial cell biology because they are found in nearly all prokaryotes, and are strikingly homologous in … pre painted galvanized steel sheet